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Joseph W. Eschbach : ウィキペディア英語版 | Joseph W. Eschbach
Joseph Wetherill Eschbach (January 21, 1933 – September 7, 2007) was an American doctor and kidney specialist whose twenty years of research starting in the 1960s led to an improvement in the treatment of anemia. Dr. Eschbach graduated from Jefferson Medical College in 1959. Eschbach was married to MaryAnn Eschbach for 51 years, they had 3 children; 5 grandchildren. == Anemia Research ==
When his mentor, Dr. Belding H. Scribner, challenged Dr. Eschbach, at the time a young nephrology researcher at the University of Washington, to find a way to correct the anemia in kidney dialysis patients, Dr. Eschbach accepted the challenge. Working with a hematologist, Dr. John W. Adamson, Eschbach looked at various forms of renal failure and the role a natural hormone, erythropoietin, had in preventing anemia. By studying the urine of sheep and other animals in the 1970s, the two scientists helped establish that erythropoietin did stimulate the bone marrow to produce red blood cells. In the 1980s, Dr. Eschbach helped lead a clinical trial at the Northwest Kidney Centers studying whether an artificial erythropoietin hormone, Epogen, manufactured by Amgen, could replace or supplement the naturally occurring hormone. The trial was successful, and its results were published in The New England Journal of Medicine in 1987: Administering artificial erythropoietin did reverse anemia in kidney patients. His research helped to inform and lead to the Food and Drug Administration's 1989 approval of the replacement hormone Epogen. Epogen and its derivative Erythropoietin Stimulating Agents remain in use throughout the world.
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